Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC013
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2023-02-28 11:48
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl PK Mertz 2x1 tbl Mirapexin a 2,1mg jedna uvece old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 11 individuals with a value less than 0.55 were subsequently diagnosed with PD. That is, 26.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.55 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 18, 'TP': 18, 'FP': 12}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 35, 'TN': 27, 'TP': 7, 'FP': 3}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 6, 'TN': 5, 'TP': 36, 'FP': 25}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 11, 'TN': 8, 'TP': 31, 'FP': 22}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.392
timePerCircleCoV 0.0880999
timePerCircleSlope 0.0146924
meanError 1.81981
tremorFreq 7.42188
tremorRelPower 24.9933
tremorGyroAmpMean 0.0244069
tremorGyroAmpSlope -0.0011293
tremorGyroAmpCoV 0.386069
tremorCoordAmpMean 0.0653264
tremorCoordAmpSlope 0.00270373
tremorCoordAmpCoV 0.292607
tremorAccAmpMean 0.0550137
tremorAccAmpSlope 0.00250326
tremorAccAmpCoV 0.352122
tremorPcRelVar 0.745846
tremorPcX 0.867376
tremorPcY -0.497654

Circle Segment 1

Duration 7.12 s, Accuracy Estimate 1.612 (lower is better)

Circle Segment 2

Duration 6.92 s, Accuracy Estimate 1.926 (lower is better)

Circle Segment 3

Duration 6.44 s, Accuracy Estimate 1.885 (lower is better)

Circle Segment 4

Duration 7.08 s, Accuracy Estimate 1.907 (lower is better)

Circle Segment 5

Duration 7.32 s, Accuracy Estimate 1.599 (lower is better)

Circle Segment 6

Duration 7.52 s, Accuracy Estimate 1.994 (lower is better)

Circle Segment 7

Duration 8.64 s, Accuracy Estimate 1.652 (lower is better)

Circle Segment 8

Duration 8.32 s, Accuracy Estimate 1.542 (lower is better)

Circle Segment 9

Duration 7.44 s, Accuracy Estimate 1.22 (lower is better)

Circle Segment 10

Duration 7.12 s, Accuracy Estimate 2.86 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 25.264
timePerSpiralCoV 0.101298
timePerSpiralSlope 0.0152571
meanError 1.68186
tremorFreq 4.98047
tremorRelPower 21.3427
tremorGyroAmpMean 0.0521769
tremorGyroAmpSlope 0.00171032
tremorGyroAmpCoV 0.344061
tremorCoordAmpMean 0.143541
tremorCoordAmpSlope 0.00120599
tremorCoordAmpCoV 0.391489
tremorAccAmpMean 0.142897
tremorAccAmpSlope 0.00149514
tremorAccAmpCoV 0.402144
tremorPcRelVar 0.789014
tremorPcX -0.893879
tremorPcY -0.448308

Spiral Segment 1

Duration 20.6 s, Accuracy Estimate 1.617 (lower is better)

Spiral Segment 2

Duration 26.28 s, Accuracy Estimate 1.761 (lower is better)

Spiral Segment 3

Duration 23.84 s, Accuracy Estimate 1.661 (lower is better)

Spiral Segment 4

Duration 24.4 s, Accuracy Estimate 1.488 (lower is better)

Spiral Segment 5

Duration 26.32 s, Accuracy Estimate 1.545 (lower is better)

Spiral Segment 6

Duration 25.36 s, Accuracy Estimate 1.528 (lower is better)

Spiral Segment 7

Duration 27.76 s, Accuracy Estimate 1.931 (lower is better)

Spiral Segment 8

Duration 24.96 s, Accuracy Estimate 1.606 (lower is better)

Spiral Segment 9

Duration 29.92 s, Accuracy Estimate 2.013 (lower is better)

Spiral Segment 10

Duration 23.2 s, Accuracy Estimate 1.667 (lower is better)

Elel

eDurationMean 0.291053
eDurationStd 0.0395781
eDurationStdnorm 0.135983
eDurationMedian 0.28
eDurationQuartdelta 0.065
eDurationQuartdeltanorm 0.232143
eDurationKurt 2.77823
eDurationTrenddiff -0.035
eDurationTrendratio 0.883333
eWidthMean 4.65537
eWidthStd 0.846395
eWidthStdnorm 0.181811
eWidthMedian 4.797
eWidthQuartdelta 0.819
eWidthQuartdeltanorm 0.170732
eWidthKurt 3.26806
eWidthTrenddiff -0.234
eWidthTrendratio 0.95122
eHeightMean 9.477
eHeightStd 1.21499
eHeightStdnorm 0.128204
eHeightMedian 9.477
eHeightQuartdelta 1.755
eHeightQuartdeltanorm 0.185185
eHeightKurt 2.44252
eHeightTrenddiff -0.936
eHeightTrendratio 0.903614
eAspectMean 0.496278
eAspectStd 0.0962808
eAspectStdnorm 0.194006
eAspectMedian 0.488511
eAspectQuartdelta 0.114554
eAspectQuartdeltanorm 0.234497
eAspectKurt 2.70986
eAspectTrenddiff 0.0525085
eAspectTrendratio 1.11175
eSlantMean 0.0260553
eSlantStd 0.172472
eSlantStdnorm 6.61945
eSlantMedian 0.031592
eSlantQuartdelta 0.159752
eSlantQuartdeltanorm 5.05673
eSlantKurt 3.11094
eSlantTrenddiff 0.067327
eRtopMean 0.803166
eRtopStd 0.117581
eRtopStdnorm 0.146397
eRtopMedian 0.822134
eRtopQuartdelta 0.142857
eRtopQuartdeltanorm 0.173764
eRtopKurt 4.58298
eRtopTrenddiff 0.0232558
eRbotMean 0.800558
eRbotStd 0.329201
eRbotStdnorm 0.411215
eRbotMedian 0.74902
eRbotQuartdelta 0.383972
eRbotQuartdeltanorm 0.512633
eRbotKurt 3.71018
eRbotTrenddiff -0.126623
eRrightMean 0.907828
eRrightStd 0.0526102
eRrightStdnorm 0.0579517
eRrightMedian 0.918329
eRrightQuartdelta 0.0706935
eRrightQuartdeltanorm 0.0769806
eRrightKurt 2.40775
eRrightTrenddiff 0.00949668
eRleftMean 0.398388
eRleftStd 0.088002
eRleftStdnorm 0.220895
eRleftMedian 0.380832
eRleftQuartdelta 0.0886385
eRleftQuartdeltanorm 0.23275
eRleftKurt 3.02189
eRleftTrenddiff -0.0168624
lDurationMean 0.451923
lDurationStd 0.0598091
lDurationStdnorm 0.132343
lDurationMedian 0.45
lDurationQuartdelta 0.0875
lDurationQuartdeltanorm 0.194444
lDurationKurt 3.07038
lDurationTrenddiff -0.055
lDurationTrendratio 0.882979
lWidthMean 6.894
lWidthStd 1.31013
lWidthStdnorm 0.190039
lWidthMedian 6.903
lWidthQuartdelta 1.1115
lWidthQuartdeltanorm 0.161017
lWidthKurt 6.23201
lWidthTrenddiff 0.117
lWidthTrendratio 1.01695
lHeightMean 24.468
lHeightStd 3.21867
lHeightStdnorm 0.131546
lHeightMedian 24.219
lHeightQuartdelta 4.24125
lHeightQuartdeltanorm 0.175121
lHeightKurt 2.54697
lHeightTrenddiff -4.095
lHeightTrendratio 0.843049
lAspectMean 0.287097
lAspectStd 0.0685557
lAspectStdnorm 0.23879
lAspectMedian 0.293785
lAspectQuartdelta 0.0933231
lAspectQuartdeltanorm 0.317657
lAspectKurt 3.58238
lAspectTrenddiff 0.0731371
lAspectTrendratio 1.29131
lSlantMean 0.01226
lSlantStd 0.119484
lSlantStdnorm 9.7458
lSlantMedian 0.00921659
lSlantQuartdelta 0.156199
lSlantQuartdeltanorm 16.9476
lSlantKurt 3.82364
lSlantTrenddiff 0.147646
lRtopMean 0.809442
lRtopStd 0.0951831
lRtopStdnorm 0.117591
lRtopMedian 0.816901
lRtopQuartdelta 0.126913
lRtopQuartdeltanorm 0.155359
lRtopKurt 3.85533
lRtopTrenddiff 0.0791667
lRbotMean 0.877562
lRbotStd 0.574315
lRbotStdnorm 0.654444
lRbotMedian 0.8125
lRbotQuartdelta 0.46658
lRbotQuartdeltanorm 0.574252
lRbotKurt 15.5575
lRbotTrenddiff -0.349807
lRrightMean 0.901635
lRrightStd 0.0551647
lRrightStdnorm 0.061183
lRrightMedian 0.913514
lRrightQuartdelta 0.0596733
lRrightQuartdeltanorm 0.0653228
lRrightKurt 3.28832
lRrightTrenddiff 0.0184336
lRleftMean 0.375575
lRleftStd 0.12622
lRleftStdnorm 0.336072
lRleftMedian 0.33617
lRleftQuartdelta 0.193241
lRleftQuartdeltanorm 0.574831
lRleftKurt 2.15492
lRleftTrenddiff -0.132096

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.816551
sumTouchScores 17.9641
meanMovementTime 0.717619
numTouches 22
undershootPercentage 0
overshootPercentage 31.8182

FITTS Long Modified

meanTouchScore 0.9375
sumTouchScores 15
meanMovementTime 1.10033
numTouches 16
undershootPercentage 0
overshootPercentage 6.25

ZigZag

numZigzags 5
timePerZigzagMean 14.952
timePerZigzagCoV 0.156088
timePerZigzagSlope 0.0337079
meanError 2.37943
tremorFreq 8.10547
tremorRelPower 25.6877
tremorGyroAmpMean 0.0408972
tremorGyroAmpSlope 0.0036446
tremorGyroAmpCoV 0.344239
tremorCoordAmpMean 0.103657
tremorCoordAmpSlope 0.000587054
tremorCoordAmpCoV 0.33168
tremorAccAmpMean 0.0941397
tremorAccAmpSlope 0.00195409
tremorAccAmpCoV 0.323114
tremorPcRelVar 0.710837
tremorPcX -0.46971
tremorPcY -0.882821

ZigZag Segment 1

Duration 12.08 s, Accuracy Estimate 3.168 (lower is better)

ZigZag Segment 2

Duration 14.8 s, Accuracy Estimate 2.027 (lower is better)

ZigZag Segment 3

Duration 18.6 s, Accuracy Estimate 2.019 (lower is better)

ZigZag Segment 4

Duration 14.56 s, Accuracy Estimate 2.164 (lower is better)

ZigZag Segment 5

Duration 14.72 s, Accuracy Estimate 2.52 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 8.888
timePerZigzagCoV 0.0802167
timePerZigzagSlope -0.040054
zigzagHeightMean 60.8387
zigzagHeightCoV 0.0337131
zigzagHeightSlope -0.0180316
meanError 0.0336449
tremorFreq 7.61719
tremorRelPower 26.5781
tremorGyroAmpMean 0.0525847
tremorGyroAmpSlope 0.00914784
tremorGyroAmpCoV 0.262287
tremorCoordAmpMean 0.128172
tremorCoordAmpSlope -0.00445466
tremorCoordAmpCoV 0.264683
tremorAccAmpMean 0.107294
tremorAccAmpSlope 0.000872566
tremorAccAmpCoV 0.254869
tremorPcRelVar 0.700626
tremorPcX 0.059752
tremorPcY -0.998213

ZigZag Offset Segment 1

Duration 10.04 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 2

Duration 8.52 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 3

Duration 9.0 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 4

Duration 8.72 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 8.16 s, Accuracy Estimate 0.063 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.83}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.55}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8283404545872839}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.6138364172606285}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.48848035038496485}